Publications

Since 2015, I have conducted research spanning synthetic chemistry, chemical biology, and pharmacology under the mentorship of leading scientists. My record of scholarly contributions includes research and review articles, posters, and oral presentations.

Research Profiles

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Bibliography

Research Articles

Carrigan-Broda, T.; Gebert, L. F. R.; Hildebrand, S.; Yamada, N.; Luu, E.; Caiazzi, J.; McHugh, N.; Echeverria, D.; Wagh, A.; Watts, J. K.; Khvorova, A.; MacRae, I. J.; Yamada, K. Programmable Recognition of Organyl 5′-Phosphates by Human Argonaute-2. J. Am. Chem. Soc. 2026. DOI: 10.1021/jacs.6c03647

Pulliam, T.; Marshall, F. E.; Carrigan-Broda, T.; Hickman, D. V; Guirgis, G.; Grubbs, G. S. The Chirped Pulse, Fourier Transform Microwave Spectrum of 1-Chloromethyl-1-Fluorosilacyclopentane. J. Mol. Spectrosc. 2023, 395, 111793. DOI: 10.1016/j.jms.2023.111793

Stocka, J.; Platakyte, R.; Hickman, D.; Carrigan-Broda, T.; Ceponkus, J.; Sablinskas, V.; Rodziewicz, P.; Guirgis, G. A. Experimental (Raman and IR) and Computational (DFT, MP2) Studies of the Conformational Diversity of 1-Chloromethyl-1-Fluorosilacyclopentane Molecule. J. Mol. Struct. 2023, 1272, 134125. DOI: 10.1016/j.molstruc.2022.134125

McFadden, T. M. C.; Platakyte, R.; Stocka, J.; Ceponkus, J.; Aleksa, V.; Carrigan-Broda, T.; Sablinskas, V.; Rodziewicz, P.; Guirgis, G. A. Experimental (Raman and IR) and Computational (DFT, MP2) Studies of Conformational Diversity of 1-Chloromethyl-1-Fluorosilacyclohexane. J. Mol. Struct. 2020, 1221, 128786. DOI: 10.1016/j.molstruc.2020.128786

Review Articles

Carrigan-Broda, T.; Yamada, K. Challenges and Advances for Metabolically Stabilizing siRNA. Nucleic Acid Insights 2026, 3 (6), 437–453. DOI: 10.18609/nai.2026.053

Poster Presentations

Carrigan-Broda, T. J.; Yamada, N.; Gebert, L.; Caiazzi, J.; MacRae, I.; Yamada, K.; Khvorova, A. Identifying Novel SiRNA Guide Strand 5′-End Modifications for Enhanced Chemical Stability, Potency, and Extrahepatic In Vivo RNAi Activity. Poster presented at the Oligonucleotide Therapeutics Society Annual Meeting, Barcelona, Spain, October 24, 2023.

Carrigan-Broda, T. J.; Yamada, N.; Gebert, L.; Caiazzi, J.; MacRae, I.; Yamada, K.; Khvorova, A. Identifying Novel SiRNA Guide Strand 5′-End Modifications for Enhanced Chemical Stability, Potency, and RNAi Activity. Poster presented at the 28th Annual Meeting of the RNA Society, Singapore, June 1, 2023.

Carrigan-Broda, T. J.; Gurgis, G. A. Conformational Preferences of Silepanes: Synthesis, Spectroscopic Characterization, and Ab Initio Modeling. Poster presented at the Colonial Academic Alliance Undergraduate Research Conference, Elon, NC, April 1, 2017.

Carrigan-Broda, T. J.; Gurgis, G. A. Synthesis and In Silico Conformational Analysis of 1,1-Difluorosilepane. Poster presented at the Southeastern Regional Meeting of the American Chemical Society, Columbia, SC, October 24, 2016.

Oral Presentations

Sablinskas, V.; Guirgis, G. A.; Rodziewicz, P.; Carrigan-Broda, T. J.; Hickman, D. V.; Macyte, J.; Ceponkus, J.; Platakyte, R.; Stocka, J. Conformational Diversity of Non-Aromatic Heterocyclic Molecular Compounds as Studied by Means of Matrix Isolation Infrared Spectroscopy. Presented at the 75th International Symposium on Molecular Spectroscopy, Urbana–Champaign, IL, June 22, 2022; WL08. DOI: 10.15278/isms.2022.WL08

Carrigan-Broda, T. J. Characterizing Gastrointestinal Bleeding via CBC and BMP. Presented at UMass Chan Physician Scientist Forum, Worcester, MA, March 1, 2021.

Carrigan-Broda, T. J. Counteracting COVID-19: A Review of Remdesivir as a Promising Antiviral. Presented at University of Massachusetts Medical School COVID-19 Research Forum: Difficult Choices in a Time of Crisis, Worcester, MA, May 26, 2020.

Marshall, F. E.; Duerden, A. J.; Moon, N.; Gillcrist, D. J.; Sedlacek, I.; Jones, G.; Carrigan-Broda, T.; Guirgis, G. A.; Grubbs, G. S. Structure Determination of 5 Membered Silane Rings Using Microwave Spectroscopy. Presented at the 73rd International Symposium on Molecular Spectroscopy, Urbana–Champaign, IL, June 19, 2018; TJ10. DOI: 10.15278/isms.2018.TJ10

Dissertations & Theses

Carrigan-Broda, T. Modulating the Activity and Metabolism of Small Interfering RNA Through 5′-Terminal Guide Strand Modification: Chemical Diversification, Pharmacological Evaluation, and Mechanistic Characterization of Novel 5′-Phosphate Mimics. PhD Dissertation, UMass Chan Medical School, Worcester, MA, 2026. DOI: 10.13028/hgaz-5z95

Carrigan-Broda, T. J. Conformational Preferences of Si-Substituted Silacycloalkanes: Synthesis, Infrared and NMR Spectroscopic Characterization, and Ab Initio Computational Modeling of Silepanes and Silinanes. Bachelor's Thesis, College of Charleston Honors College, Charleston, SC, 2017.